Study With Me : Introduction to Blood Transfusion 33
SECTION 1 : Haematology
Questions and Answers
Question 179:
What distinguishes thalassaemia major from thalassaemia minor?
Answer: Thalassaemia major is a more severe form, often transfusion-dependent, causing enlargement of the liver and spleen, and bone expansion.
Question 180:
What is sickle cell anaemia, and what causes it?
Answer: Sickle cell anaemia is an inherited disorder seen in the Arabian Peninsula, Asia, and Africa, caused by a structural defect in the beta-globin chain of the haemoglobin molecule, leading to the formation of HbS and haemolysis.
Question 181:
What happens during a sickle cell crisis?
Answer: During a sickle cell crisis, red cells change into a sickle or crescent shape, can become lodged in capillaries, and have a decreased lifespan.
Question 182:
In sickle cell anaemia, when is transfusion necessary?
Answer: Transfusion may be necessary in sickle cell anaemia cases where routine transfusion helps lower the concentration of HbS.
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