A Seminar on Immune-Mediated Cell Destruction at the 1981 AABB Annual Meeting: A Book Review

Seminar on Immune-Mediated Cell Destruction at the 1981 AABB Annual Meeting”

This post highlights the notable seminar on immune-mediated cell destruction that took place during the 1981 AABB Annual Meeting in Chicago. Renowned experts delivered insightful lectures on various aspects of red cell and platelet destruction, providing valuable insights into this field. Here’s a summary of the seminar:

1. Overview of immune red cell destruction:

   • Presented by Paul Engelfriet from The Netherlands.
   • Provided a comprehensive overview of immune-mediated red cell destruction.

2. In vivo cell destruction:

   • Discussed by George Garratty, shedding light on the mechanisms of cell destruction within the body.

3. Red cell survival studies using 51-Cr:

   • Addressed by Patrick Mollison, who presented studies involving the use of 51-Cr to evaluate red cell survival.

4. Hemolytic transfusion reactions:

   • Reviewed by Howard Taswell, highlighting the occurrence and implications of hemolytic transfusion reactions.

5. The Crossmatch: Past, Present, and Future:

   • Explored by Hal Oberman, emphasizing the crucial role of the crossmatch test in ensuring ABO compatibility.

6. Platelet antibody tests and immune destruction:

   • Richard Kahn described platelet antibody tests, and Dick Aster covered the subject of immune destruction of platelets.

7. Immune neutrophil destruction:

   • Concluded the lectures with a presentation by Tom Stossel, focusing on the immune destruction of neutrophils.

Additionally, James Danielli and Jonathan Singer were awarded the prestigious 1981 Karl Landsteiner Memorial Award for their groundbreaking research on the structure of the lipid bilayer of the red cell membrane and the fluid mosaic membrane model. Although their lectures were presented separately, their contributions were highly significant.

Overall, the seminar brought together esteemed experts in the field and provided valuable insights into immune-mediated cell destruction, covering various aspects of red cell, platelet, and neutrophil destruction.