Study With Me : Introduction to Blood Transfusion 39

Question 201:

What is classic haemophilia (haemophilia A), and how is it inherited?
Classic haemophilia (haemophilia A) is inherited as a sex-linked recessive trait, characterized by a lack of functional FVIII. Females are carriers, while affected males have a bleeding tendency.
Sources: [[1](https://www.ncbi.nlm.nih.gov/books/NBK7014/)]

Question 202:

How is Christmas disease (haemophilia B) inherited, and what distinguishes it from haemophilia A?
Christmas disease (haemophilia B) is inherited as a sex-linked recessive trait, with a lack of FIX. Its clinical signs are similar to haemophilia A, and laboratory testing may be required to distinguish between the two.
Sources: [[1](https://www.ncbi.nlm.nih.gov/books/NBK7014/)]

Question 203:

What is von Willebrand's disease (VWD), and how is it inherited?
Von Willebrand's disease (VWD) is inherited as an autosomal dominant trait, not sex-linked. It results from abnormalities in von Willebrand's factor (vWF), a glycoprotein crucial for platelet adhesion and the coagulation cascade.
Sources: [[4](https://en.wikipedia.org/wiki/Von_Willebrand_disease)], [[5](https://www.nature.com/articles/gim9201165)]